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Index > Protein center > CCND3(Gene name) > Human
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  • CCND3 (Gene name),
  • G1/S-specific cyclin-D3 (Protein name ),  CCND3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CCND3;
    Protein name:
    G1/S-specific cyclin-D3;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.
    Function:
    Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
    Subcellular Location:
    Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
    Protein Attributes:
    Sequence length:
    292
    Sequence:
    50:
    MELLCCEGTR | HAPRAGPDPR | LLGDQRVLQS | LLRLEERYVP | RASYFQCVQR | 
    100:
    EIKPHMRKML | AYWMLEVCEE | QRCEEEVFPL | AMNYLDRYLS | CVPTRKAQLQ | 
    150:
    LLGAVCMLLA | SKLRETTPLT | IEKLCIYTDH | AVSPRQLRDW | EVLVLGKLKW | 
    200:
    DLAAVIAHDF | LAFILHRLSL | PRDRQALVKK | HAQTFLALCA | TDYTFAMYPP | 
    250:
    SMIATGSIGA | AVQGLGACSM | SGDELTELLA | GITGTEVDCL | RACQEQIEAA | 
    292:
    LRESLREASQ | TSSSPAPKAP | RGSSSQGPSQ | TSTPTDVTAI | HL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human G1/S-specific cyclin-D3
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    ELISA Kit for Human G1/S-specific cyclin-D3
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    ELISA Kit for Human G1/S-specific cyclin-D3
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    ELISA Kit for Human G1/S-specific cyclin-D3
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    CLIA Kit for Human G1/S-specific cyclin-D3
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    CLIA Kit for Human G1/S-specific cyclin-D3
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    96T
    CLIA Kit for Human G1/S-specific cyclin-D3
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    U0587m
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    CLIA Kit for Human G1/S-specific cyclin-D3
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    Packing:
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    Polyclonal Antibody for Human G1/S-specific cyclin-D3
    Polyclonal Antibody for Human G1/S-specific cyclin-D3
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    P0587Rb-h
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    Packing:
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    Polyclonal Antibody for Human G1/S-specific cyclin-D3
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    Polyclonal Antibody for Human G1/S-specific cyclin-D3
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human G1/S-specific cyclin-D3
    Monoclonal Antibody for Human G1/S-specific cyclin-D3
    Monoclonal Antibody for Human G1/S-specific cyclin-D3
    Monoclonal Antibody for Human G1/S-specific cyclin-D3
    Protein for Human G1/S-specific cyclin-D3
    Protein for Human G1/S-specific cyclin-D3
    Protein for Human G1/S-specific cyclin-D3
    Protein for Human G1/S-specific cyclin-D3

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    References
    1. 1.
      "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins."
      Xiong Y. , Menninger J. , Beach D. , Ward D.C.
      Genomics13:575-584(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-259
    2. 2.
      "Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene."
      Motokura T. , Keyomarsi K. , Kronenberg H.M. , Arnold A.
      J. Biol. Chem.267:20412-20415(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      NIEHS SNPs program
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-259
    4. 4.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ALA-259
      tissue: Cervix carcinoma.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4);VARIANT ALA-259
      tissue: Synovium.
      tissue: Thymus.
      tissue: Umbilical cord blood.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-259
    7. 7.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-259
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    10. 10.
      "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes."
      Inaba T. , Matsushime H. , Valentine M. , Roussel M.F. , Sherr C.J. , Look A.T.
      Genomics13:565-574(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 52-237
      tissue: Placenta.
    11. 11.
      "New functional activities for the p21 family of CDK inhibitors."
      LaBaer J. , Garrett M.D. , Stevenson L.F. , Slingerland J.M. , Sandhu C. , Chou H.S. , Fattaey A. , Harlow E.
      Genes Dev.11:847-862(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK4 AND CDKN1A
    12. 12.
      "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity."
      Liu W. , Sun M. , Jiang J. , Shen X. , Sun Q. , Liu W. , Shen H. , Gu J.
      Biochem. Biophys. Res. Commun.321:954-960(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF5;FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3."
      Shen X. , Yang Y. , Liu W. , Sun M. , Jiang J. , Zong H. , Gu J.
      FEBS Lett.573:139-146(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF3K
    14. 14.
      "Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK 'inhibitors'."
      Bockstaele L. , Kooken H. , Libert F. , Paternot S. , Dumont J.E. , de Launoit Y. , Roger P.P. , Coulonval K.
      Mol. Cell. Biol.26:5070-5085(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK4; CDKN2A AND CDKN1B
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    17. 17.
      "F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest."
      Chen B.B. , Glasser J.R. , Coon T.A. , Mallampalli R.K.
      Oncogene31:2566-2579(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY SCF(FBXL2)
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "The structure of CDK4/cyclin D3 has implications for models of CDK activation."
      Takaki T. , Echalier A. , Brown N.R. , Hunt T. , Endicott J.A. , Noble M.E.
      Proc. Natl. Acad. Sci. U.S.A.106:4171-4176(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH CDK4
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